姚雅莉(Ya-Li Yao)
狀態 副教授
姓名 姚雅莉(Ya-Li Yao)
電子郵件 yyao@asia.edu.tw
職稱 專任副教授
分機 04-23323456#1842
辦公室/研究室 I523
學歷 美國南佛羅里達大學 醫學微生物及免疫學 博士
研究領域 PAX3 在瓦登博革氏症候群中的轉錄調控機制
授課領域 基因工程、內分泌學、癌症生物學、醫學生物技術、分子生物學、免疫學、生物技術研究法、高等分子生物學
教師歷程檔案 https://research.asia.edu.tw/TchEportfolio/index_1/910100537
Office Hours 111-1教師在校時程表_姚 雅 莉老師
網站 http://mlsb.asia.edu.tw/files/13-1119-73643.php?Lang=zh-tw
專長 基因表現與轉錄調控、癌症生物學 PML 核體與急性前骨髓性細胞白血病的治病機轉 細胞核與染色質結構探討
經歷 2007至今 亞洲大學副教授
年度 論文名稱
2021 林玉茹(Yu-Ru Lin)、劉又瑜(You-Yu Liu)、藍信企(Hsin-Chi Lan)、沈炯祺(Chiung-Chyi Shen)、姚雅莉(Ya-Li Yao)*、楊文明(Wen-MingYang), M33 condenses chromatin through nuclear body formation and methylation of both histone H3 lysine 9 and lysine 27, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2021
2021 藍信企(Hsin-Chi Lan)、杜亭慧(Ting-Huei Du)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), Ocular disease-associated mutations diminish the mitotic chromosome retention ability of PAX6, Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 2021
2016 梁雅珍(Ya-Chen Liang)、李佳瑾(Chia-Chin Lee)、姚雅莉(Ya-Li Yao)*、賴建成(Chien-Chen Lai)、M. Lienhard Schmitz、楊文明(Wen-Ming Yang)*, SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies, Scientific Reports, vol.6 pp.26509-, 2016
2015 吳祖方(Tsu-Fang Wu)、姚雅莉(Ya-Li Yao)*、賴羿如(I-Lu Lai)、賴建成(Chien-Chen Lai)、林珮綸(Pei-Lun Lin)、楊文明(Wen-Ming Yang)*, Loading of PAX3 to Mitotic Chromosomes Is Mediated by Arginine Methylation and Associated with Waardenburg Syndrome, JOURNAL OF BIOLOGICAL CHEMISTRY, vol.290 no.33 pp.20556-20564, 2015
2014 謝鳳書(Feng-Shu Hsieh)、陳乃慈(Nai-Tzu Chen)、姚雅莉(Ya-Li Yao)、王詩芸(Shi-Yun Wang)、陳健尉(Jeremy J.W. Chen)、賴建成(Chien-Chen Lai)、楊文明(Wen-Ming Yang)*, The transcriptional repression activity of STAF65γ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases, Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, vol.1839 no.2014 pp.579-591, 2014
2014 吳祖方(TSU-FANG WU)、姚雅莉(Ya-Li Yao)、賴羿如(I-LU LAI)、李宗翰(TSUNG-HAN LEE)、D. ALAN UNDERHILL、楊文明(WEN-MING YANG), PAX3 Loads onto Pericentromeric Heterochromatin During S Phase Through PARP1, ANTICANCER RESEARCH, vol.34 no.9 pp.4717-4722, 2014
2013 梁雅珍(Ya-Chen Liang)、許巧雨(Chiao-Yu Hsu)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang)*, PARP-2 regulates cell cycle-related genes through histone deacetylation and methylation independently of poly(ADP-ribosyl)ation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol.431 no.2013 pp.58-64, 2013
2011 姚雅莉(Ya-Li Yao)、梁雅珍(Ya-Chen Liang)、黃懷慧(Huai-Huei Huang)、楊文明(Wen-Ming Yang)*, FKBPs in chromatin modification and cancer, CURRENT OPINION IN PHARMACOLOGY, vol.11 no.4 pp.301-307, 2011
2010 賴羿如(I-Lu Lai)、林東屏(Tung-Ping Lin)、姚雅莉(Ya-Li Yao)、林靜宜(Ching-Yi Lin)、謝美如(Mei-Ju Hsieh)、楊文明(Wen-Ming Yang)*, Histone Deacetylase 10 Relieves Repression on the Melanogenic Program By Maintaining the Deacetylation Status of Repressors, JOURNAL OF BIOLOGICAL CHEMISTRY, vol.285 no.10 pp.7187-7196, 2010
2010 姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang)*, Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, vol.2011 pp.146493-, 2010
2007 2. Lai IL、Wang SY、姚雅莉(Ya-Li Yao)、Yang WM, Transcriptional and subcellular regulation of the TRIP-Br family, GENE, vol.388 no.1-2 pp.102-109, 2007
2006 Hsieh MJ、姚雅莉(Ya-Li Yao)、Lai IL、Yang WM, Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol.349 no.2 pp.573-581, 2006
2005 姚雅莉(Ya-Li Yao)、Yang WM, Nuclear proteins: promising targets for cancer drugs, CURRENT CANCER DRUG TARGETS, vol.5 no.8 pp.595-610, 2005
2004 Rezai-Zadeh N、Tsai SC、Wen YD、姚雅莉(Ya-Li Yao)、Yang WM、Seto E, Histone deacetylases: purification of the enzymes substrates and assay conditions., Methods in Enzymology, vol.377 pp.167-179, 2004
2003 Rezai-Zadeh N、Zhang X、Namour F、Fejer G、Wen YD、姚雅莉(Ya-Li Yao)、Gyory I、Wright K、Seto E, Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1, GENES & DEVELOPMENT, vol.17 no.8 pp.1019-1029, 2003
2003 姚雅莉(Ya-Li Yao)、Yang WM, The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activities, JOURNAL OF BIOLOGICAL CHEMISTRY, vol.278 no.43 pp.42560-42568, 2003
發表日期 論文名稱
2018.06 邱奕嘉(Yi-Chia Chiu)、廖宥媃(You-Rou Liao)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), The function of Waardenburg Syndrome mutants of PAX3 during DNA replication , International Conference on Biomedical Sciences and the 15th Symposium of the Frontiers of Biomedical Sciences, Jun. 2018, Taichung, Taiwan
2018.03 林珮綸(Pei-Lun Lin)、葉昱妏(Yu-Wen Yeh)、楊文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), KAP1 Serves as a Scaffold Protein for HP1α and PIASy in HP1α SUMOylation for Nascent Chromatin Targeting , 第33屆生物醫學聯合學術年會, Mar. 2018, 台灣 台北市 國防醫學院
2018.03 劉思龍(Sih-Long Liu)、楊文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), SUMO1, SUMO2, and SUMO3 SUMOylation Mediate HP1β Loading on Pericentric Heterochromatin , 第33屆生物醫學聯合學術年會, Mar. 2018, 台灣 台北市 國防醫學院
2018.03 鄭佩汝(Pei-Ru Cheng)、葉昱妏(Yu-Wen Yeh)、楊文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), HP1α SUMOylation by SUMO2 and SUMO3, Distinguishing from SUMO1 in heterochromatin loading , 第33屆生物醫學聯合學術年會, Mar. 2018, 台灣 台北市 國防醫學院
2016.07 廖宥媃(You-Rou Liao)、劉筱君(Hsiao-Chun Liu)、藍信企(Hsin-Chi Lan)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), PARP1 PARylates PAX3 and facilitates PAX3 loading onto replication forks , 2016 International Symposium on Biomedical Sciences, Jul. 2016, Taichung, Taiwan
2016.03 林玉茹(Yu-Ru Lin)、郭依萍(Yi-Ping Kuo)、吳祖方(Tsu-Fang Wu)、梁雅珍(Ya-Chen Liang)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), Waardenburg syndrome, associated PAX3 mutant, PAX3Q282X, induces the formation of heterochromatin-like structures via histone methyltransferases G9a and SUV39H1 - Keystone Symposia on Molecular and Celllualr Biolgoy, Chromatin and Epigenetics, Mar. 2016, Whistler, British Columbia, Canada
2016.03 王竣彥(Chun-Yen Wang)、吳祖方(Tsu-Fang Wu)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), PAX3, FOXO1 loads on heterochromatin and causes replication stress - 第31屆生物醫學聯合學術年會, Mar. 2016, 台灣台北市 國防醫學院
2016.01 劉又瑜(You Yu LIu)、林玉茹(Yu-Ru Lin)、楊文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), SUV39H1 and G9a mediate the formation of M33, induced heterochromatin - The Twenty-fourth Symposium on Recent Advances in Cellular and Molecular Biology, Jan. 2016, 台灣屏東縣恆春鎮
2016.01 劉筱君(Hsiao-Chun Liu)、吳祖方(Tsu-Fang Wu)、藍信企(Hsin-Chi Lan)、王漢宇(Han-Yu Wang)、王峻彥(Chun-Yen Wang)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), Cellular effects caused by PAX3 Waardenburg Syndrome mutants during DNA replication , The Twenty-fourth Symposium on Recent Advances in Cellular and Molecular Biology, Jan. 2016, 台灣屏東縣恆春鎮
2015.02 李依儒(Yi-Zu Lee)、林柏穎(Bo-Ying Lin)、賴羿如(I-Lu Lai)、楊文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), KAP1 and HP1 Increases Protein Import and Promotes DNA Replication in Micronucle , The Twenty-third Symposium on Recent Advances in Cellular and Molecular Biology, Feb. 2015, Ken-Ding 墾丁, Taiwan
2014.05 梁雅珍(Ya-Chen Liang)、賴泉豪(Chun-Hao Lai)、姚雅莉(Ya-Li Yao)、李佳瑾(Chia-Chin Lee)、賴建成(Chien-Chen Lai)、楊文明(Wen-Ming Yang), A Novel SUMO5, Associated PML Nuclear Body Controls Transcription Factor PAX3 and Melanin Production - Cold Spring Harbor Asia Meetings: Epigenetics, Chromatin and Transcription, May. 2014, Suzhou, China
2014.03 姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), Pax3 Mutants in Waardenburg Syndrome Associate with Histone Modifiers , 2014 The 29th Joint Annual Conference of Biomedical Science, Mar. 2014, Taipei, Taiwan
2013.01 謝岱芳(Tai-Fang Hsieh)、賴羿如(I-Lu Lai)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), KAP1 acts as a scaffold protein to promote the efficiency of HP1α SUMOylation by PIASy , The Twenty-first Symposium on Recent Advances in Cellular and Molecular Biology, Jan. 2013, Ken-Ding 墾丁, Taiwan
2012.03 吳俊穎、蔡育勳、姚雅莉(Ya-Li Yao), Identification of HP, β-CD/ cinnamaldehyde complex and its bioactivities - 生醫年會, Mar. 2012, 台北
2011.03 HDAC10 Modulates Melanogenesis , Fourth China Medical University and Asia University Joint Conference on Biotechnology, Mar. 2011, 中國醫藥大學
2011.02 黃雅絹(Ya-Chuan Huang)、林靜宜(Ching-Yi Lin)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), Molecular Analysis of Cellular Functions of PAX3, FKHR - Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology, Feb. 2011, 高雄
2011.02 林玉茹(Yu-Ru Lin)、梁雅珍(Ya-Chen Liang)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), The Mechanism of M33 Nuclear Body Formation and Its Role in Transcriptional Regulation , Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology, Feb. 2011, 高雄
2011.01 梁雅珍(Ya-Chen Liang)、李佳瑾(Chia-Chin Lee)、M. Lienhard Schmitz、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), The Formation of PML Nuclear Body is Induced by a Novel SUMO1 Variant, SUMO13 , EMBO Conference Series: Nuclear Structure and Dynamics, Jan. 2011, France
2010.01 賴泉豪(Chun-Hao Lai)、梁雅珍(Ya-Chen Liang)、李佳瑾(Chia-Chin Lee)、高孝偉(Shiao-Wei Kuo)、楊文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), Transcriptional Activity of PAX3 is Regulated by SUMO proteins , Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, Jan. 2010, 墾丁
2010.01 張筱如(Shiao-Ru Chang)、賴羿如(I-Lu Lai)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), The Transcriptional Activity of KAP1 is Modulated by Oligomeric/Monomeric Form , Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, Jan. 2010, 墾丁
2010.01 杜亭慧(TIng-Huei Du)、梁雅珍(Ya-Chen Liang)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), The Cellular and Molecular Functions of PAX6 in Transcriptional Regulation , Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, Jan. 2010, 墾丁
2010.01 吳芷瑄(Chih-Hsuan Wu)、梁雅珍(Ya-Chen Liang)、賴羿如(I-Lu Lai)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), Studies of SIRT6 in Transcriptional Regulation , Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, Jan. 2010, 墾丁
2009.03 施雅方(Ya-Fang Shi)、林靜宜(Ching-Yi Lin)、楊文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), Molecular mechanism of Pax3, FKHR in transcriptional regulation - Second China Medical University and Asia University Joint Conference on Biotechnology, Mar. 2009, 中國醫藥大學
2009.02 謝鳳書(Feng-Shu Hsieh)、姚雅莉(Ya-Li Yao)、王詩芸(Shi-Yun Wang)、楊文明(Wen-Ming Yang), Molecular Mechanism of STAF65gamma in Transcriptional Repression , Seventeenth Symposium on Recent Advances in Cellular and Molecular Biology, Feb. 2009, 墾丁
2009.02 黃沛錞、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), FKBP25 Regulates Transcription through Histone Demethylase, JMJD2A , Seventeenth Symposium on Recent Advances in Cellular and Molecular Biology, Feb. 2009, 墾丁
2008.01 李佳瑾(Chia-Chin Lee)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), Transcriptional activity of PML is regulated by SUMO1 , Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology, Jan. 2008, 墾丁
2008.01 林靜宜(Ching-Yi Lin)、謝美如(Mei-Ju Hsieh)、楊文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), The mechanism of Pax3, FKHR in transcriptional regulation - Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology, Jan. 2008, 墾丁
2007.02 劉雨如(Yu-Ru Liu)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), FKBP25 promotes cell growth through nuclear shuttling , Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology, Feb. 2007, 墾丁
2007.02 許巧雨(Chiao-Yu Hsu)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), PARP, 2 represses transcription by its PARP activity and associates with HDACs - Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology, Feb. 2007, 墾丁
2007.02 邱瑞頤(Jui-Yi Chiu)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), MTA represses transcription through histone methylation , Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology, Feb. 2007, 墾丁
2006.01 陳乃慈(Nai-Tzu Chen)、王詩芸(Shi-Yun Wang)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), Mechanistic studies of STAF65gamma in transcriptional regulation , Fourteenth Symposium on Recent Advances in Cellular and Molecular Biology, Jan. 2006, 墾丁
2006.01 陳麗蓮(Li-Lien Chen)、姚雅莉(Ya-Li Yao)、楊文明(Wen-Ming Yang), Mechanistic studies of ZFP42 in transcriptional regulation , Fourteenth Symposium on Recent Advances in Cellular and Molecular Biology, Jan. 2006, 墾丁
2005.12 謝美如(Mei-Ju Hsieh)、姚雅莉(Ya-Li Yao)、賴羿如(I-Lu Lai)、楊文明(Wen-Ming Yang), Molecular mechanisms of KAP1 in transcriptional repression , The ninth Asian-Pacific Conference on Transcription, Dec. 2005, National Health Research Institutes, Taiwan
2004.02 台灣生命倫理學會 中區說明會 , Feb. 2004, 中國醫藥大學
2003.09 第六屆工程科技與中西醫學應用研討會 組織工程與幹細胞研究Symposium , Sep. 2003, 台中健康暨管理學院
計畫名稱 參與人 計畫期間
類泛素修飾作用對急性前骨髓性白血病致病機轉的影響 (107-asia-02) 姚雅莉(Ya-Li Yao) 2019.03 ~ 2020.02
以生醫大數據分析為基礎的精準癌症醫療研究 (106PFD0850068) 蔡進發(JEFFREY J. P. TSAI)、姚雅莉(Ya-Li Yao) 2017.08 ~ 2018.07
DNA 修復中心形成過程中類泛素化與蛋白質功能網路之建構 (106-asia-09) 姚雅莉(Ya-Li Yao) 2017.04 ~ 2018.03
DNA 複制及修復系統及其蛋白質交互作用網路之穩定性-以細胞微核為模式驗證 DNA 修復過程中之蛋白質交互作用 (105-asia-12) 姚雅莉(Ya-Li Yao) 2016.04 ~ 2017.03
以細胞微核為模式研究 KAP1 利用蛋白間交互作用修復 DNA 雙股斷裂的機制 (104-aisa-04) 姚雅莉(Ya-Li Yao) 2016.03 ~ 2017.02
建制癌症生物學中染色體異常事件資料庫及探討染色質形成機制-KAP1調控異染色質形成機制之探討 (103-asia-05) 姚雅莉(Ya-Li Yao) 2015.02 ~ 2016.01
KAP1 在細胞微核中修復 DNA 雙股斷裂之分子機制探討 (102-asia-08) 姚雅莉(Ya-Li Yao) 2014.02 ~ 2015.01
SUMO修飾化在形成DNA修復中心的重要性 (101-asia-39) 姚雅莉(Ya-Li Yao) 2013.02 ~ 2014.01
Pax3 與染色體之間的交互作用在瓦登博革氏症候群與橫紋肌肉瘤中扮演的角色 (NSC98-2311-B-468-001-MY3 ) 姚雅莉(Ya-Li Yao) 2011.08 ~ 2012.07
Pax3 與染色體之間的交互作用在瓦登博革氏症候群與橫紋肌肉瘤中扮演的角色 (NSC98-2311-B-468-001-MY3 ) 姚雅莉(Ya-Li Yao) 2010.08 ~ 2011.07
Pax3 與染色體之間的交互作用在瓦登博革氏症候群與橫紋肌肉瘤中扮演的角色 (NSC98-2311-B-468-001-MY3) 姚雅莉(Ya-Li Yao) 2010.08 ~ 2011.07
Molecular pathogenetic analysis of Waardenburg syndrom (學人短訪 99-2-15) 姚雅莉(Ya-Li Yao) 2010.07 ~ 2010.09
Pax3 與染色體之間的交互作用在瓦登博革氏症候群與橫紋肌肉瘤中扮演的角色 (NSC98-2311-B-468-001-MY3 ) 姚雅莉(Ya-Li Yao) 2009.08 ~ 2010.07
Pax3 亞核分布情形之分析 (學人短訪 98-2-21 ) 姚雅莉(Ya-Li Yao) 2009.07 ~ 2009.09
由分子層面探討ZFP42 之轉錄抑制機制 (NSC95-2311-B-468 -001 -MY3 ) 姚雅莉(Ya-Li Yao) 2008.08 ~ 2009.07
Molecular Mechanism of Stem Cell Maintenance by ZFP42 (97-2-13 ) 姚雅莉(Ya-Li Yao) 2008.07 ~ 2008.09
Molecular Mechanism of Stem Cell Maintenance by ZFP42 (學人短訪 97-2-13) 姚雅莉(Ya-Li Yao) 2008.07 ~ 2008.09
由分子層面探討ZFP42 之轉錄抑制機制 (NSC95-2311-B-468 -001 -MY3 ) 姚雅莉(Ya-Li Yao) 2007.08 ~ 2008.07
Molecular Analysis of the Transcriptional Repression Mechansim of ZFP42 (學人短訪 96-2) 姚雅莉(Ya-Li Yao) 2007.07 ~ 2007.09
由分子層面探討ZFP42 之轉錄抑制機制 (NSC95-2311-B-468 -001 -MY3) 姚雅莉(Ya-Li Yao) 2006.08 ~ 2007.07
ZFP42轉錄抑制功能之探討 (NSC94-2311-B-468-002- ) 姚雅莉(Ya-Li Yao) 2005.08 ~ 2006.07
ZFP42之功能性蛋白質體學研究 (NSC93-2311-B-468-001- ) 姚雅莉(Ya-Li Yao) 2004.08 ~ 2005.07
形相似但功能不同:ZFP42生物功能的探討 (NSC92-2311-B-468-001- ) 姚雅莉(Ya-Li Yao) 2003.08 ~ 2004.07