姚雅莉(Ya-Li Yao)
姓名 姚雅莉(Ya-Li Yao)
电子邮件 yyao@asia.edu.tw
状态 副教授
职称 专任副教授
分机 04-23323456#1842
办公室/研究室 I523
学历 美国南佛罗里达大学 医学微生物及免疫学 博士
研究领域 PAX3 在瓦登博革氏症候群中的转录调控机制
授课领域 基因工程、内分泌学、癌症生物学、医学生物技术、分子生物学、免疫学、生物技术研究法、高等分子生物学
教师历程档案 https://research.asia.edu.tw/TchEportfolio/index_1/910100537
Office Hours 109-2在校时间表
网站 http://mlsb.asia.edu.tw/files/13-1119-73643.php?Lang=zh-tw
专长 基因表现与转录调控、癌症生物学 PML 核体与急性前骨髓性细胞白血病的治病机转 细胞核与染色质结构探讨
经历 2007至今 亚洲大学副教授
年度 论文名称
2021 林玉茹(Yu-Ru Lin)、刘又瑜(You-Yu Liu)、蓝信企(Hsin-Chi Lan)、沈炯祺(Chiung-Chyi Shen)、姚雅莉(Ya-Li Yao)*、杨文明(Wen-MingYang), M33 condenses chromatin through nuclear body formation and methylation of both histone H3 lysine 9 and lysine 27, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
2016 梁雅珍(Ya-Chen Liang)、李佳瑾(Chia-Chin Lee)、姚雅莉(Ya-Li Yao)*、赖建成(Chien-Chen Lai)、M. Lienhard(M. Lienhard Schmitz)、杨文明(Wen-Ming Yang)*, SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies, Scientific Reports, vol.6 pp.26509-
2015 吴祖方(Tsu-Fang Wu)、姚雅莉(Ya-Li Yao)*、赖羿如(I-Lu Lai)、赖建成(Chien-Chen Lai)、林珮纶(Pei-Lun Lin)、杨文明(Wen-Ming Yang)*, Loading of PAX3 to Mitotic Chromosomes Is Mediated by Arginine Methylation and Associated with Waardenburg Syndrome, JOURNAL OF BIOLOGICAL CHEMISTRY, vol.290 no.33 pp.20556-20564
2014 吴祖方(TSU-FANG WU)、姚雅莉(Ya-Li Yao)、赖羿如(I-LU LAI)、李宗翰(TSUNG-HAN LEE)、D. ALAN UNDE(D. ALAN UNDERHILL)、杨文明(WEN-MING YANG), PAX3 Loads onto Pericentromeric Heterochromatin During S Phase Through PARP1, ANTICANCER RESEARCH, vol.34 no.9 pp.4717-4722
2014 谢凤书(Feng-Shu Hsieh)、陈乃慈(Nai-Tzu Chen)、姚雅莉(Ya-Li Yao)、王诗芸(Shi-Yun Wang)、陈健尉(Jeremy J.W. Chen)、赖建成(Chien-Chen Lai)、杨文明(Wen-Ming Yang)*, The transcriptional repression activity of STAF65γ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases, Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, vol.1839 no.2014 pp.579-591
2013 梁雅珍(Ya-Chen Liang)、许巧雨(Chiao-Yu Hsu)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang)*, PARP-2 regulates cell cycle-related genes through histone deacetylation and methylation independently of poly(ADP-ribosyl)ation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol.431 no.2013 pp.58-64
2011 姚雅莉(Ya-Li Yao)、梁雅珍(Ya-Chen Liang)、黄怀慧(Huai-Huei Huang)、杨文明(Wen-Ming Yang)*, FKBPs in chromatin modification and cancer, CURRENT OPINION IN PHARMACOLOGY, vol.11 no.4 pp.301-307
2010 姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang)*, Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, vol.2011 pp.146493-
2010 赖羿如(I-Lu Lai)、林东屏(Tung-Ping Lin)、姚雅莉(Ya-Li Yao)、林静宜(Ching-Yi Lin)、谢美如(Mei-Ju Hsieh)、杨文明(Wen-Ming Yang)*, Histone Deacetylase 10 Relieves Repression on the Melanogenic Program By Maintaining the Deacetylation Status of Repressors, JOURNAL OF BIOLOGICAL CHEMISTRY, vol.285 no.10 pp.7187-7196
2007 2. Lai IL(2. Lai IL)、Wang SY(Wang SY)、姚雅莉(Ya-Li Yao)、Yang WM(Yang WM), Transcriptional and subcellular regulation of the TRIP-Br family, GENE, vol.388 no.1-2 pp.102-109
2006 Hsieh MJ(Hsieh MJ)、姚雅莉(Ya-Li Yao)、Lai IL(Lai IL)、Yang WM(Yang WM), Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol.349 no.2 pp.573-581
2005 姚雅莉(Ya-Li Yao)、Yang WM(Yang WM), Nuclear proteins: promising targets for cancer drugs, CURRENT CANCER DRUG TARGETS, vol.5 no.8 pp.595-610
2004 Rezai-Zadeh(Rezai-Zadeh N)、Tsai SC(Tsai SC)、Wen YD(Wen YD)、姚雅莉(Ya-Li Yao)、Yang WM(Yang WM)、Seto E(Seto E), Histone deacetylases: purification of the enzymes substrates and assay conditions., Methods in Enzymology, vol.377 pp.167-179
2003 姚雅莉(Ya-Li Yao)、Yang WM(Yang WM), The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activities, JOURNAL OF BIOLOGICAL CHEMISTRY, vol.278 no.43 pp.42560-42568
2003 Rezai-Zadeh(Rezai-Zadeh N)、Zhang X(Zhang X)、Namour F(Namour F)、Fejer G(Fejer G)、Wen YD(Wen YD)、姚雅莉(Ya-Li Yao)、Gyory I(Gyory I)、Wright K(Wright K)、Seto E(Seto E), Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1, GENES & DEVELOPMENT, vol.17 no.8 pp.1019-1029
论文名称
邱奕嘉(Yi-Chia Chiu)、廖宥媃(You-Rou Liao)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), The function of Waardenburg Syndrome mutants of PAX3 during DNA replication , International Conference on Biomedical Sciences and the 15th Symposium of the Frontiers of Biomedical Sciences, Taichung, Taiwan
郑佩汝(Pei-Ru Cheng)、叶昱妏(Yu-Wen Yeh)、杨文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), HP1α SUMOylation by SUMO2 and SUMO3, Distinguishing from SUMO1 in heterochromatin loading , 第33届生物医学联合学术年会, 台湾 台北市 国防医学院
刘思龙(Sih-Long Liu)、杨文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), SUMO1, SUMO2, and SUMO3 SUMOylation Mediate HP1β Loading on Pericentric Heterochromatin , 第33届生物医学联合学术年会, 台湾 台北市 国防医学院
林珮纶(Pei-Lun Lin)、叶昱妏(Yu-Wen Yeh)、杨文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), KAP1 Serves as a Scaffold Protein for HP1α and PIASy in HP1α SUMOylation for Nascent Chromatin Targeting , 第33届生物医学联合学术年会, 台湾 台北市 国防医学院
廖宥媃(You-Rou Liao)、刘筱君(Hsiao-Chun Liu)、蓝信企(Hsin-Chi Lan)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), PARP1 PARylates PAX3 and facilitates PAX3 loading onto replication forks , 2016 International Symposium on Biomedical Sciences, Taichung, Taiwan
王竣彦(Chun-Yen Wang)、吴祖方(Tsu-Fang Wu)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), PAX3, FOXO1 loads on heterochromatin and causes replication stress , 台湾台北市 国防医学院
林玉茹(Yu-Ru Lin)、郭依萍(Yi-Ping Kuo)、吴祖方(Tsu-Fang Wu)、梁雅珍(Ya-Chen Liang)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), Waardenburg syndrome, associated PAX3 mutant, PAX3Q282X, induces the formation of heterochromatin, Whistler, British Columbia, Canada
刘筱君(Hsiao-Chun Liu)、吴祖方(Tsu-Fang Wu)、蓝信企(Hsin-Chi Lan)、王汉宇(Han-Yu Wang)、王峻彦(Chun-Yen Wang)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), Cellular effects caused by PAX3 Waardenburg Syndrome mutants during DNA replication , The Twenty, 台湾屏东县恒春镇
刘又瑜(You Yu LIu)、林玉茹(Yu-Ru Lin)、杨文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), SUV39H1 and G9a mediate the formation of M33, induced heterochromatin , 台湾屏东县恒春镇
李依儒(Yi-Zu Lee)、林柏颖(Bo-Ying Lin)、赖羿如(I-Lu Lai)、杨文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), KAP1 and HP1 Increases Protein Import and Promotes DNA Replication in Micronucle , The Twenty, Ken-Ding 垦丁, Taiwan
梁雅珍(Ya-Chen Liang)、赖泉豪(Chun-Hao Lai)、姚雅莉(Ya-Li Yao)、李佳瑾(Chia-Chin Lee)、赖建成(Chien-Chen Lai)、杨文明(Wen-Ming Yang), A Novel SUMO5, Associated PML Nuclear Body Controls Transcription Factor PAX3 and Melanin Production , Suzhou, China
姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), Pax3 Mutants in Waardenburg Syndrome Associate with Histone Modifiers , 2014 The 29th Joint Annual Conference of Biomedical Science, Taipei, Taiwan
谢岱芳(Tai-Fang Hsieh)、赖羿如(I-Lu Lai)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), KAP1 acts as a scaffold protein to promote the efficiency of HP1α SUMOylation by PIASy , The Twenty, Ken-Ding 垦丁, Taiwan
吴俊颖、蔡育勳、姚雅莉(Ya-Li Yao), Identification of HP, β, 台北
HDAC10 Modulates Melanogenesis , Fourth China Medical University and Asia University Joint Conference on Biotechnology, 中国医药大学
林玉茹(Yu-Ru Lin)、梁雅珍(Ya-Chen Liang)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), The Mechanism of M33 Nuclear Body Formation and Its Role in Transcriptional Regulation , Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology, 高雄
黄雅绢(Ya-Chuan Huang)、林静宜(Ching-Yi Lin)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), Molecular Analysis of Cellular Functions of PAX3, FKHR , 高雄
吴芷瑄(Chih-Hsuan Wu)、梁雅珍(Ya-Chen Liang)、赖羿如(I-Lu Lai)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), Studies of SIRT6 in Transcriptional Regulation , Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, 垦丁
杜亭慧(TIng-Huei Du)、梁雅珍(Ya-Chen Liang)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), The Cellular and Molecular Functions of PAX6 in Transcriptional Regulation , Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, 垦丁
张筱如(Shiao-Ru Chang)、赖羿如(I-Lu Lai)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), The Transcriptional Activity of KAP1 is Modulated by Oligomeric/Monomeric Form , Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, 垦丁
赖泉豪(Chun-Hao Lai)、梁雅珍(Ya-Chen Liang)、李佳瑾(Chia-Chin Lee)、高孝伟(Shiao-Wei Kuo)、杨文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), Transcriptional Activity of PAX3 is Regulated by SUMO proteins , Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, 垦丁
施雅方(Ya-Fang Shi)、林静宜(Ching-Yi Lin)、杨文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), Molecular mechanism of Pax3, FKHR in transcriptional regulation , 中国医药大学
黄沛錞、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), FKBP25 Regulates Transcription through Histone Demethylase, JMJD2A , Seventeenth Symposium on Recent Advances in Cellular and Molecular Biology, 垦丁
谢凤书(Feng-Shu Hsieh)、姚雅莉(Ya-Li Yao)、王诗芸(Shi-Yun Wang)、杨文明(Wen-Ming Yang), Molecular Mechanism of STAF65gamma in Transcriptional Repression , Seventeenth Symposium on Recent Advances in Cellular and Molecular Biology, 垦丁
林静宜(Ching-Yi Lin)、谢美如(Mei-Ju Hsieh)、杨文明(Wen-Ming Yang)、姚雅莉(Ya-Li Yao), The mechanism of Pax3, FKHR in transcriptional regulation , 垦丁
李佳瑾(Chia-Chin Lee)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), Transcriptional activity of PML is regulated by SUMO1 , Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology, 垦丁
邱瑞颐(Jui-Yi Chiu)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), MTA represses transcription through histone methylation , Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology, 垦丁
许巧雨(Chiao-Yu Hsu)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), PARP, 2 represses transcription by its PARP activity and associates with HDACs , 垦丁
刘雨如(Yu-Ru Liu)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), FKBP25 promotes cell growth through nuclear shuttling , Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology, 垦丁
陈丽莲(Li-Lien Chen)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), Mechanistic studies of ZFP42 in transcriptional regulation , Fourteenth Symposium on Recent Advances in Cellular and Molecular Biology, 垦丁
陈乃慈(Nai-Tzu Chen)、王诗芸(Shi-Yun Wang)、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), Mechanistic studies of STAF65gamma in transcriptional regulation , Fourteenth Symposium on Recent Advances in Cellular and Molecular Biology, 垦丁
谢美如(Mei-Ju Hsieh)、姚雅莉(Ya-Li Yao)、赖羿如(I-Lu Lai)、杨文明(Wen-Ming Yang), Molecular mechanisms of KAP1 in transcriptional repression , The ninth Asian, National Health Research Institutes, Taiwan
台湾生命伦理学会 中区说明会 , 中国医药大学
第六届工程科技与中西医学应用研讨会 组织工程与干细胞研究Symposium , 台中健康暨管理学院
梁雅珍(Ya-Chen Liang)、李佳瑾(Chia-Chin Lee)、M. Lienhard Schmitz、姚雅莉(Ya-Li Yao)、杨文明(Wen-Ming Yang), The Formation of PML Nuclear Body is Induced by a Novel SUMO1 Variant, SUMO13 , EMBO Conference Series: Nuclear Structure and Dynamics, France
计画名称 参与人 计画期间
类泛素修饰作用对急性前骨髓性白血病致病机转的影响 (107-asia-02) 姚雅莉(Ya-Li Yao) 2019.03 ~ 2020.02
以生医大数据分析为基础的精准癌症医疗研究 (106PFD0850068) 蔡进发(JEFFREY J. P. TSAI)、姚雅莉(Ya-Li Yao) 2017.08 ~ 2018.07
DNA 修复中心形成过程中类泛素化与蛋白质功能网络之建构 (106-asia-09) 姚雅莉(Ya-Li Yao) 2017.04 ~ 2018.03
DNA 复制及修复系统及其蛋白质交互作用网络之稳定性-以细胞微核为模式验证 DNA 修复过程中之蛋白质交互作用 (105-asia-12) 姚雅莉(Ya-Li Yao) 2016.04 ~ 2017.03
以细胞微核为模式研究 KAP1 利用蛋白间交互作用修复 DNA 双股断裂的机制 (104-aisa-04) 姚雅莉(Ya-Li Yao) 2016.03 ~ 2017.02
建制癌症生物学中染色体异常事件数据库及探讨染色质形成机制-KAP1调控异染色质形成机制之探讨 (103-asia-05) 姚雅莉(Ya-Li Yao) 2015.02 ~ 2016.01
KAP1 在细胞微核中修复 DNA 双股断裂之分子机制探讨 (102-asia-08) 姚雅莉(Ya-Li Yao) 2014.02 ~ 2015.01
SUMO修饰化在形成DNA修复中心的重要性 (101-asia-39) 姚雅莉(Ya-Li Yao) 2013.02 ~ 2014.01
Pax3 与染色体之间的交互作用在瓦登博革氏症候群与横纹肌肉瘤中扮演的角色 (NSC98-2311-B-468-001-MY3 ) 姚雅莉(Ya-Li Yao) 2011.08 ~ 2012.07
Pax3 与染色体之间的交互作用在瓦登博革氏症候群与横纹肌肉瘤中扮演的角色 (NSC98-2311-B-468-001-MY3) 姚雅莉(Ya-Li Yao) 2010.08 ~ 2011.07
Pax3 与染色体之间的交互作用在瓦登博革氏症候群与横纹肌肉瘤中扮演的角色 (NSC98-2311-B-468-001-MY3 ) 姚雅莉(Ya-Li Yao) 2010.08 ~ 2011.07
Molecular pathogenetic analysis of Waardenburg syndrom (学人短访 99-2-15) 姚雅莉(Ya-Li Yao) 2010.07 ~ 2010.09
Pax3 与染色体之间的交互作用在瓦登博革氏症候群与横纹肌肉瘤中扮演的角色 (NSC98-2311-B-468-001-MY3 ) 姚雅莉(Ya-Li Yao) 2009.08 ~ 2010.07
Pax3 亚核分布情形之分析 (学人短访 98-2-21 ) 姚雅莉(Ya-Li Yao) 2009.07 ~ 2009.09
由分子层面探讨ZFP42 之转录抑制机制 (NSC95-2311-B-468 -001 -MY3 ) 姚雅莉(Ya-Li Yao) 2008.08 ~ 2009.07
Molecular Mechanism of Stem Cell Maintenance by ZFP42 (学人短访 97-2-13) 姚雅莉(Ya-Li Yao) 2008.07 ~ 2008.09
Molecular Mechanism of Stem Cell Maintenance by ZFP42 (97-2-13 ) 姚雅莉(Ya-Li Yao) 2008.07 ~ 2008.09
由分子层面探讨ZFP42 之转录抑制机制 (NSC95-2311-B-468 -001 -MY3 ) 姚雅莉(Ya-Li Yao) 2007.08 ~ 2008.07
Molecular Analysis of the Transcriptional Repression Mechansim of ZFP42 (学人短访 96-2) 姚雅莉(Ya-Li Yao) 2007.07 ~ 2007.09
由分子层面探讨ZFP42 之转录抑制机制 (NSC95-2311-B-468 -001 -MY3) 姚雅莉(Ya-Li Yao) 2006.08 ~ 2007.07
ZFP42转录抑制功能之探讨 (NSC94-2311-B-468-002- ) 姚雅莉(Ya-Li Yao) 2005.08 ~ 2006.07
ZFP42之功能性蛋白质体学研究 (NSC93-2311-B-468-001- ) 姚雅莉(Ya-Li Yao) 2004.08 ~ 2005.07
形相似但功能不同:ZFP42生物功能的探讨 (NSC92-2311-B-468-001- ) 姚雅莉(Ya-Li Yao) 2003.08 ~ 2004.07
课程类别 课程代码 课程名称 年度
大学日间部 TM300149B 学辅时间(三) 110
大学日间部 TM300097A 分子生物学 110
大学日间部 TM300018A 分子生物学 110
大学日间部 TM300160A 精准生物医学概论 110
大学日间部 TM300097A 分子生物学 110
大学日间部 TK300086B 环境微生物及免疫学(含实验) 110
大学日间部 TK300086A 环境微生物及免疫学(含实验) 110
大学日间部 TK300086B 环境微生物及免疫学(含实验) 110
大学日间部 TK300086A 环境微生物及免疫学(含实验) 110
大学日间部 GRG00251E 共通专业英语文:医护英文-中级 110
大学日间部 TM300148B 学辅时间(二) 109
大学日间部 TM300137A 内分泌学 109
大学日间部 TM300101B 免疫学 109
大学日间部 TM300101A 免疫学 109
大学日间部 TD300061A 环境微生物及免疫学(含实验) 109