Ching-Yao Chang
Status Professors
Name Ching-Yao Chang
Job title Professor
Tel 04-23323456#1863
Office/Lab I421/H407
Education Ph.D., Chemistry, National Chung-Hsing University, Taiwan
Areas of Research Chemistry, Organic chemistry
Teaching Courses Chemistry, Organic Chemistry, Analytic Chemistry
Office Hours
Year Paper Title
2021 Peng-Tai Tien、Chia-Hung Lin(Chia-Hung Lin)*、張清堯(Ching-Yao Chang), Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell, MEDIATORS OF INFLAMMATION, vol.2021 no.6660640 pp.1-11
2021 Yu-An Hsu、張清堯(Ching-Yao Chang), Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model, CURRENT ISSUES IN MOLECULAR BIOLOGY, vol.43 pp.716-727
2020 Peng?Tai Tien、張清堯(Ching-Yao Chang), Perfluorooctanoic acid in indoor particulate matter triggers oxidative stress and inflammation in corneal and retinal cells, Scientific Reports, vol.1 no.10 pp.15702-15713
2020 En-Shyh Lin、張清堯(Ching-Yao Chang)、萬磊(Lei Wan)*, Ablation of Galectin-12 Inhibits Atherosclerosis through Enhancement of M2 Macrophage Polarization, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol.21 no.15 pp.5511-5524
2020 張清堯(Ching-Yao Chang)、萬磊(Lei Wan)*, Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells, JOURNAL OF BIOMEDICAL SCIENCE, vol.27 no.24 pp.1-9
2019 Chang-Ching Wei、張清堯(Ching-Yao Chang)、萬磊*, PM2.5 and NOx exposure promote myopia: clinical evidence and experimental proof, ENVIRONMENTAL POLLUTION, vol.254 pp.113031-113038
2018 萬磊*、張清堯, The synergistic effects of orthokeratology and atropine in slowing the progression of myopia, Journal of clinical medicine, vol.7 no.9 pp.259-267
2018 Yu-An Hsu、張清堯(Ching-Yao Chang)、萬磊*, Galectin-12 is Involved in Corn Silk-Induced Anti-Adipogenesis and Anti-Obesity Effects, The American journal of Chinese medicine, vol.46 no.5 pp.1-19
2018 Chia-Wen Lo、萬磊*、, Allyl isothiocyanate ameliorates obesity by inhibiting galectin-12, MOLECULAR NUTRITION & FOOD RESEARCH
2018 魏長菁(Chang-Ching Wei)、萬磊*、, Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression, EBioMedicine
2017 Yung-Jen Kun、、萬磊*、、, Kawasaki disease increases the incidence of myopia, Biomed Research International
2016 Hsu, Yu-An、張清堯(Ching-Yao Chang)、萬磊*, The anti-proliferative effects of type I IFN involve STAT6-mediated regulation of SP1 and BCL6, CANCER LETTERS, vol.375 pp.303-312
2016 Lin, C.-H.、萬磊*, Cold-water extracts of Grifola frondosa and its purified active fraction inhibit hepatocellular carcinoma in vitro and in vivo, EXPERIMENTAL BIOLOGY AND MEDICINE, vol.241 no.13 pp.1374-1385
2016 萬磊*、張清堯(Ching-Yao Chang), Galectin-12 enhances inflammation by promoting M1 polarization of macrophages and reduces insulin sensitivity in adipocytes, GLYCOBIOLOGY, vol.26 pp.732-744
2016 Lin, H.-J.、萬磊*, Role of Chronic Inflammation in Myopia Progression: Clinical Evidence and Experimental Validation, EBioMedicine, vol.10 pp.269-281
2015 張清堯(Ching-Yao Chang)、萬磊*, Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway, BMC CANCER, vol.15 no.958 pp.1-12
2015 張清堯(Ching-Yao Chang)、萬磊*, MUTYH Gene Polymorphisms as Risk Factors for Rheumatoid Arthritis, BioMed Research International, vol.2015 pp.1-8
2014 張清堯(Ching-Yao Chang)、萬磊(Lei Wan)*, [PDF] Association of Interleukin-16 Polymorphisms with Graves' Disease in a Taiwanese Population, CHINESE JOURNAL OF PHYSIOLOGY, vol.57 no.2 pp.69-75
2014 張清堯(Ching-Yao Chang)*, An Efficient Synthesis of the C27-C45 Fragment of Lagunamide A, a Cyclodepsipeptide with Potent Cytotoxic and Antimalarial Properties, TETRAHEDRON-ASYMMETRY, vol.25 no.2 pp.187-192
2014 張清堯(Ching-Yao Chang), Structurally well-characterized zinc complexes bearing iminebenzotriazole phenoxide ligands: Synthesis, photoluminescent properties and catalysis for carbon dioxide/epoxide coupling, Journal of Organometallic Chemistry, vol.754 pp.16-25
2013 張清堯(Ching-Yao Chang)、萬磊(Lei Wan)*, Genetic variation in NOS2A is associated with a sustained virological response to peginterferon plus ribavirin therapy for chronic hepatitis C in Taiwanese Chinese, JOURNAL OF MEDICAL VIROLOGY, vol.85 no.7 pp.1206-1214
2013 黃素華(Su-Hua Huang)、張清堯(Ching-Yao Chang), Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses, Evidence-based Complementary and Alternative Medicine, vol.2013 pp.1-11
2012 張清堯(Ching-Yao Chang)、林振文(CHENG-WEN LIN), Rhein Induces Apoptosis in Human Breast Cancer Cells, Evidence-based Complementary and Alternative Medicine, vol.2012 pp.1-8
2012 張清堯(Ching-Yao Chang), Determination of trace indium in urine after preconcentration with a chelating resin-packed minicolumn, JOURNAL OF SEPARATION SCIENCE, vol.35 no.7 pp.846-852
2011 張清堯(Ching-Yao Chang), A Short and Efficient Synthesis of a Novel Diarylheptanoid Isolated from Pleuranthodium Racemigerum, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol.58 no.3 pp.286-289
2011 張清堯(Ching-Yao Chang), Efficient synthesis of the C1-C9 fragment of 7,8-O-isopropylidene protected iriomoteolide 3a derivative, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol.58 no.1 pp.31-34
2011 賴淑玲(Shu Ling Lai), (4Z)-4-[(2,6-Diisopropylanilino)(phenyl)methylidene]- 3-methy-1-phenyl-1H-pyrazol-5(4H)-one, ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, vol.E67 pp.o324-
2010 張清堯(Ching-Yao Chang), Pd2(dba)3-promoted synthesis of 3-substituted 4-aryl-1,2,3,6-tetrahydropyridine, TETRAHEDRON LETTERS, vol.51 pp.4886-4889
2010 許成光(Cheng-Kuang Hsu)、王建國(Chien-Kuo Wang)、張清堯(Ching-Yao Chang), Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells, ANTICANCER RESEARCH, vol.30 pp.1189-1194
2010 張清堯(Ching-Yao Chang), BF3-promoted synthesis of spiroindenyl heterocycles, TETRAHEDRON LETTERS, vol.51 pp.3154-3158
2010 張清堯(Ching-Yao Chang), Solannm lyratum extract affected immune response in normal and leukemia murine animal in vivo, HUMAN & EXPERIMENTAL TOXICOLOGY, vol.29 no.1 pp.359-367
2010 張清堯(Ching-Yao Chang), BF3-promoted synthesis of diarylhexahydrobenzo[f]isoquinoline, ORGANIC LETTERS, vol.12 pp.1176-1179
2009 張清堯(Ching-Yao Chang), Rhein induced apoptosis through the endoplasmic reticulum stress, caspase- and mitochondria-dependent pathways in SCC-4 human tongue squamous cancer cells, IN VIVO, vol.23 no.2 pp.309-316
2009 張清堯(Ching-Yao Chang)*, Efficient total syntheses of louisianins C and D, TETRAHEDRON, vol.65 no.4 pp.748-751
2008 Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, vol.32 pp.355-359
2007 Supercritical fluid extraction of imidazole drugs from cosmetic and pharmaceutical products, JOURNAL OF FOOD AND DRUG ANALYSIS, vol.15 no.1 pp.25-32
2007 Practical synthesis of (-)-α-aminobenzolactam via nitration-cyclization of L-homophenylalanine ethyl ester, HETEROCYCLES, vol.71 pp.323-330
2007 Asymmetric zinc-Reformatsky reaction of Evans chiral imide with acetophenones and its application to the stereoselective synthesis of triazole antifungal agents, TETRAHEDRON-ASYMMETRY, vol.18 pp.949-962
2007 Identification of a novel septin 4 protein binding to human herpesvirus 8 kaposin A protein using a phage display cDNA library, JOURNAL OF VIROLOGICAL METHODS, vol.143 pp.65-72
2006 First total synthesis of louisianin A, JOURNAL OF ORGANIC CHEMISTRY, vol.71 pp.6302-6304
2006 Formal Synthesis of the ACE Inhibitor Benazepril HCl via an Asymmetric Aza-Michael Reaction, MOLECULES, vol.11 no.8 pp.641-648
Year Book Title
2015 張清堯(Ching-Yao Chang)、劉惠銘、陳明仁、楊雅甄(Ya-Chen Yang)、張竣維(Hebron C. Chang), 有機化學, 東華書局, 2015/06
2014 普通化學, 高立圖書, 2014/01
Project Title Participator Period
具高度細胞毒性之生物分子lagunamide A和B的合成研究 (NSC 100-2113-M-468-001) 2011.08 ~ 2012.07
具高度細胞毒性之大環分子iriomoteolide-3a及其7,8-O-異丙基衍生物的合成研究 (99-2113-M-468-001) 張清堯(Ching-Yao Chang) 2010.07 ~ 2011.07
脂質代謝活性促進劑—雙帖類生物鹼Nigellamines及其衍生物的合成研究 (96-2113-M-468-001) 張清堯(Ching-Yao Chang) 2007.08 ~ 2008.07
單萜類生物鹼(-)-oxerine的不對稱合成 (95-2113-M-468-001) 張清堯(Ching-Yao Chang) 2006.08 ~ 2007.07
SC 115細胞抑制劑-Louisianin A的合成(2/2) (94-2113-M-468-002) 張清堯(Ching-Yao Chang) 2005.08 ~ 2006.07
SC 115細胞抑制劑-Louisianin A的合成(1/2) (94-2113-M-468-001) 張清堯(Ching-Yao Chang) 2005.01 ~ 2004.07
Category Course Code Course Title Year
大學日間部 TM300003A 普通化學 111